Skin conditions like psoriasis and eczema are inflammatory diseases related to impaired immune function that form unsightly lesions and scaly skin.62-63 Traditional medicines like Ayurveda have used guggul extract (internally and externally) to alleviate these types of skin lesions.62
Pharmaceutical drugs such as infliximab and etanercept are used to treat conditions like psoriasis are believed to be effective because the inhibit the production and activity of the inflammatory protein tumor necrosis factor (TNF). Research indicates that guggulsterols also inhibit synthesis and expression of TNF, which may provide the scientific explanation for guggul’s traditional use to treat these conditions.64